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Author : Root | Date : 10 January 2017 | Comments : 0 |
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Formulating Poorly Water Soluble Drugs, 2nd Edition

Formulating Poorly Water Soluble Drugs, 2nd Edition (AAPS Advances in the Pharmaceutical Sciences Series, v. 22) by Robert O. Williams III, Alan B. Watts, Dave Miller
2016 | ISBN: 3319426079 | English | 779 pages | PDF | 19 MB

The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientistís approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compoundís physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop

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